2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140518
    N-(Azido-PEG3)-N-bis(PEG4-acid) 2112731-54-9 98.0%
    N-(Azido-PEG3)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-bis(PEG4-acid)
  • HY-133389
    Mal-PEG36-NHS ester 2136297-07-7
    Mal-PEG36-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG36-NHS ester
  • HY-140460
    Fmoc-N-PEG7-acid 1863885-74-8 99.21%
    Fmoc-N-amido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-N-PEG7-acid
  • HY-140461
    Fmoc-NH-PEG10-acid 2101563-45-3 98.0%
    Fmoc-NH-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG10-acid
  • HY-W042657
    Octaethylene glycol monomethyl ether 25990-96-9 99.84%
    Octaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Octaethylene glycol monomethyl ether
  • HY-126894
    Bis-PEG9-acid 1268488-70-5
    Bis- PEG9- acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis- PEG9- acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG9-acid
  • HY-140683
    m-PEG5000-azide 98.0%
    m-PEG5000-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG5000-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG5000-azide
  • HY-168937D
    HS-PEG3500-NH2 hydrochloride 99.81%
    HS-PEG-NH2 (Mn 3500) hydrochloride is a bifunctional cross-linker that can be used to synthesize PEG hydrogels.
    HS-PEG3500-NH2 hydrochloride
  • HY-140700
    m-PEG20000-NHS ester 92451-01-9 98.0%
    m-PEG20000-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG20000-NHS ester
  • HY-117104
    Hydroxy-PEG4-acid 937188-59-5 99.81%
    Hydroxy-PEG4-acid is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG4-acid
  • HY-W002887
    N-Boc-cis-4-Hydroxy-D-proline 135042-12-5 98.0%
    N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the Synthesis of ADCs or PROTACs.
    N-Boc-cis-4-Hydroxy-D-proline
  • HY-140472
    Boc-NH-PEG12-CH2CH2COOH 1415981-79-1 98.0%
    Boc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG12-CH2CH2COOH
  • HY-140407
    Bis-aminooxy-PEG1 93460-33-4
    Bis-aminooxy-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-aminooxy-PEG1
  • HY-141205
    Hydroxy-PEG9-Boc 2055042-66-3 ≥98.0%
    Hydroxy-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG9-Boc
  • HY-141370
    Bromo-PEG1-CH2-Boc 157759-50-7 ≥98.0%
    Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG1-CH2-Boc
  • HY-141240
    Hydroxy-PEG2-C2-methyl ester 457897-73-3 98.48%
    Hydroxy-PEG2-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG2-C2-methyl ester
  • HY-118808
    Propargyl-PEG2-NHBoc 869310-84-9
    Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-NHBoc
  • HY-120918
    NH2-PEG7 1425973-14-3 98.0%
    NH2-PEG7 is a PROTAC linker, which refers to the PEG composition. NH2-PEG7 can be used in the synthesis of the PROTAC PARP1 degrader iRucaparib-AP6.
    NH2-PEG7
  • HY-134696
    Azido-PEG6-CH2COOH 880129-82-8 ≥98.0%
    Azido-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-CH2COOH
  • HY-117519
    Amino-Tri-(carboxyethoxymethyl)-methane 174362-95-9 98.0%
    Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-Tri-(carboxyethoxymethyl)-methane
PROTAC Linkers Isoform Comparison

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