PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4098)
Related Products (4098)
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PROTAC Linkers Isoform Comparison
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Bromo-PEG1-CH2-Boc
0 ImagesCat. No.: HY-141370CAS No.: 157759-50-7
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Biotin-PEG3-C3-NH2
0 ImagesCat. No.: HY-140902ACAS No.: 183896-00-6
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Hydroxy-PEG2-C2-methyl ester
0 ImagesSynonyms: Methyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate
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Propargyl-PEG2-NHBoc
0 ImagesCat. No.: HY-118808CAS No.: 869310-84-9Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Azido-PEG6-CH2COOH
0 ImagesCat. No.: HY-134696CAS No.: 880129-82-8Azido-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bis-aminooxy-PEG4
0 ImagesCat. No.: HY-140410CAS No.: 98627-72-6
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Bromoacetamido-PEG3-azide
0 ImagesCat. No.: HY-140825CAS No.: 940005-81-2Bromoacetamido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamido-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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m-PEG11-NHS ester
0 ImagesCat. No.: HY-141105CAS No.: 3119903-67-9
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Azido-PEG5-triethoxysilane
0 ImagesCat. No.: HY-140856Azido-PEG5-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-triethoxysilane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-(Azido-PEG2)-N-Boc-PEG3-NHS ester
0 ImagesCat. No.: HY-140559CAS No.: 2093153-85-4N-(Azido-PEG2)-N-Boc-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Boc-PEG3-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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NH2-PEG5-OH
0 ImagesNH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Bis-PEG6-acid
0 ImagesCat. No.: HY-120587CAS No.: 119189-70-7
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Bromoacetamido-PEG2-C2-NHS ester
0 ImagesCat. No.: HY-141386CAS No.: 1353011-78-5
